tag:blogger.com,1999:blog-4592848841591637472024-03-21T22:09:13.491+11:00Prostate Cancer Journal" ... the medium through which I will monitor my treatment in the battle against cancer"Unknownnoreply@blogger.comBlogger162125tag:blogger.com,1999:blog-459284884159163747.post-58693917317497513912013-11-27T09:09:00.002+11:002013-11-27T09:12:36.519+11:00Short-Course ADT Passes Test in High-Risk Prostate Cancer
ORLANDO -- Men with node-negative high-risk prostate cancer lived just as long with a 50% shorter duration of androgen deprivation therapy (ADT) compared with standard duration therapy, results of a randomized clinical trial showed.
After a median follow-up of 6.5 years, 76.2% of patients who were treated with pelvic radiotherapy and androgen blockade remained alive after 18 months ofUnknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-66250388375309272002013-09-29T17:22:00.002+10:002013-11-27T09:13:23.766+11:00Treatment of Hormone Resistant Prostate Cancer
The following are treatment options for castrate-resistant prostate cancer (also called hormone-refractory prostate cancer). The types of treatments given are based on the unique needs of the person with cancer.
Hormonal therapy
Some form of hormonal therapy must always be continued even if the cancer is growing despite the hormonal Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-54976887080822347802013-08-26T14:40:00.002+10:002013-11-27T09:14:29.043+11:00Managing the Patient With a Rising PSA Following ADTAlthough prostate cancer is initially responsive to hormone manipulation, the responsiveness of tumor cells to ADT in patients with metastatic disease begins to wane rather quickly, with a median time to disease progression of less than 2 years,[37,38] and a median survival of 12-16 months from the time that androgen independence is established.[38]
&Unknownnoreply@blogger.com2tag:blogger.com,1999:blog-459284884159163747.post-45658066734253509792012-02-19T20:17:00.004+11:002013-11-27T09:21:38.556+11:00Handling relapse after Prostate Cancer Treatment - 2
Defining biochemical recurrence
As you are probably aware, both normal prostate cells and prostate cancer cells manufacture PSA. That is why the PSA level should fall to undetectable levels in men treated with radical prostatectomy, in which the prostate is removed, but is not likely to drop to zero in men treated with radiation therapy, even when treatment is successful.
This is because Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-20620077084641533702012-02-12T10:17:00.074+11:002013-11-27T09:22:59.204+11:00How to handle a relapse after treatment for prostate cancer - Part One
Marc B. Garnick, M.D., discusses what biochemical recurrence means and what your options are
“Am I going to die?”
This is the first question a patient usually asks me when a follow-up blood test reveals that his prostate-specific antigen (PSA) level has risen after he has already undergone treatment for prostate cancer (usually a radical prostatectomy or radiation therapy).
The Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-91756091387805626462009-08-03T11:42:00.000+10:002009-08-03T11:44:35.362+10:00Key Event In Prostate Cancer Progression DiscoveredScienceDaily (July 28, 2009) — A study led by researchers at the Ohio State University Comprehensive Cancer Center and Dana-Farber Cancer Institute reveals how late-stage, hormone-independent prostate tumors gain the ability to grow without need of hormones.The onset of hormone-independent growth marks an advanced and currently incurable stage of prostate cancer.The study, published in the July Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-6066638803585189022009-06-22T16:14:00.000+10:002009-06-22T16:16:55.041+10:00Longer Hormone Treatment May Improve Prostate Cancer OutlookEuropean and U.S. studies find similar resultsWEDNESDAY, June 10 (HealthDay News) -- Men with moderately advanced prostate cancer who get hormone-blocking drugs after radiation therapy do better when the drug treatment is continued for two or more years after an initial six-month regimen, a European study has found.The results pretty much mirror those of a similar American trial reported in May, Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-29663778427813882802009-06-22T15:53:00.001+10:002009-06-22T15:55:22.228+10:00New Approach For Treating Recurrent Prostate Cancer On The HorizonScienceDaily (June 15, 2009) — A new study shows that an alpha-particle emitting radiopeptide—radioactive material bound to a synthetic peptide, a component of protein—is effective for treating prostate cancer in mice, according to researchers at SNM's 56th Annual Meeting in Toronto. The results could eventually result in a significant breakthrough in prostate cancer treatment, especially for Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-27585512907283542312009-06-20T11:52:00.001+10:002009-06-20T11:55:13.059+10:00Dramatic Outcomes In Prostate Cancer StudyScienceDaily (June 19, 2009) — Two Mayo Clinic patients whose prostate cancer had been considered inoperable are now cancer free thanks in part to an experimental drug therapy that was used in combination with standardized hormone treatment and radiation therapy. The men were participating in a clinical trial of an immunotherapeutic agent called MDX-010 or ipilimumab.In these two cases, Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-61121338340782512722009-06-11T15:24:00.001+10:002009-06-11T15:27:15.292+10:00Hormone Therapy May Confer More Aggressive Properties To Prostate TumorsScienceDaily (June 10, 2009) — Hormone therapy is often given to patients with advanced prostate cancer. While it is true that the treatment prevents growth of the tumour, it also changes its properties. Some of these changes may result in the tumour becoming more aggressive and more liable to form metastases.This is one of the conclusion of a thesis presented at the Sahlgrenska Academy, Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-35320523445707695912009-06-03T14:15:00.001+10:002009-06-03T14:18:06.853+10:00From Prostate Imaging to Prostate Cancer ImagingDENVER—Magnetic resonance imaging (MRI) is customarily used for prostate imaging. However, by modifying a chemotherapy drug with a radioactive component, scientists should be able to image prostate cancer specifically while simultaneously providing therapy for the disease.John P. Michael Sedelaar, PhD, MD, a postdoctoral research fellow at Johns Hopkins University, presented these findings at theUnknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-52424923809058578102009-06-03T10:01:00.002+10:002009-06-03T10:05:46.781+10:00ASCO: Gene Test Predicts Prostate CancerORLANDO, June 2 -- A set of six genes, measured in a blood test, can be used to tell whether a man has prostate cancer, a researcher said here.In a case-control study, the six-gene panel outperformed a standard test -- age-adjusted prostate specific antigen -- in distinguishing between men with cancer and those without, according to Robert Ross, M.D., of Dana-Farber Cancer Institute in Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-26440253441710430822009-05-29T10:24:00.000+10:002009-05-29T10:25:32.765+10:00New Blood Test Greatly Reduces False-positives In Prostate Cancer ScreeningScienceDaily (May 28, 2009) — A new blood test used in combination with a conventional prostate-specific antigen (PSA) screening sharply increases the accuracy of prostate cancer diagnosis, and could eliminate tens of thousands of unneeded, painful, and costly prostate biopsies annually, according to a study led by researchers at Dana-Farber Cancer Institute.At the annual meeting of the American Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-43647894289191898012009-05-27T09:51:00.000+10:002009-05-27T09:53:23.256+10:00Carbohydrate Restriction May Slow Prostate Tumor GrowthScienceDaily (May 26, 2009) — Restricting carbohydrates, regardless of weight loss, appears to slow the growth of prostate tumors, according to an animal study being published this week by researchers in the Duke Prostate Center."Previous work here and elsewhere has shown that a diet light in carbohydrates could slow tumor growth, but the animals in those studies also lost weight, and because we Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-43371788910499794652009-05-23T10:04:00.001+10:002009-05-23T10:06:19.486+10:00Protein That Suppresses Androgen Receptors Could Improve Prostate Cancer Diagnosis, TreatmentScienceDaily (May 20, 2009) — A protein that helps regulate expression of androgen receptors could prove a new focal point for staging and treating testosterone-fueled prostate cancer, Medical College of Georgia researchers say.Levels of the protein, βarrestin2, are lower in some prostate cancer cells than in normal prostate cells while expression of testosterone-fed androgen receptors is higher,Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-46502382834372662562009-05-20T16:10:00.001+10:002009-05-20T16:14:13.754+10:00Quick Test For Prostate CancerScienceDaily (May 18, 2009) — A new 3-minute test could help in diagnosing prostate cancer, the most common cancer in men in the UK, according to scientists.Researchers have developed the test by using light energy to measure the level of citrate in fluid samples from the prostate gland. The technique could provide the basis of a rapid means of detecting prostate cancer in the future. Almost a Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-7907679467873597512009-05-19T09:56:00.001+10:002009-05-19T09:58:13.384+10:00Molecular Pathway Behind Invasive Prostate CancersScienceDaily (May 18, 2009) — University of Cincinnati (UC) cancer and cell biologists have identified a new molecular pathway key to the development of invasive prostate cancers.In a preclinical study led by Maria Diaz-Meco, PhD, the UC team found that simultaneous inactivation of two particular genes—known as PTEN and Par-4—caused the rapid development of invasive prostate cancer tumors in miceUnknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-83776378803364132742009-05-15T12:22:00.002+10:002009-05-15T12:25:51.423+10:00Men With Prostate Cancer Worry Less About Recurrence Than Their Spouses DoResearchers at The Mount Sinai Medical Center in New York have found that, when it comes to worrying about the recurrence of prostate cancer, male patients worry less than their female spouses or partners. The study was presented at the 30th annual meeting of the Society of Behavioral Medicine in Montreal.In a study of 96 men and their spouses or partners, Michael Diefenbach, Ph.D., Associate Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-72119928835667317092009-05-15T12:16:00.002+10:002009-05-15T12:19:53.766+10:00Video: Da Vinci ProstatectomyThe following video provides an overview of the radical prostatectomy with the daVinci System from www.intuitivesurgical.com. Dr. J.H. Witt www.pznw.de St. Antonius Hospital Gronau, Germany.Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-70461973945577140002009-05-15T09:51:00.001+10:002009-05-15T09:53:57.683+10:00Scientists Find New Way to Identify Deadly Forms of Prostate CancerResearchers have discovered a new method to help doctors identify the most aggressive forms of prostate cancer.A struggle for medical professionals in identifying prostate cancer is determining which forms are very aggressive and will require surgery and which forms are dormant and can be left untreated without risk.Reporting in the British Journal of Cancer Research, scientists noted that Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-87540992783572214352009-04-30T11:14:00.003+10:002009-04-30T11:22:29.137+10:00AUA: Statin Benefits Linked to Prostate Cancer, BPH, EDBy Charles Bankhead, Staff Writer, MedPage TodayPublished: April 28, 2009Reviewed by Zalman S. Agus, MD; Emeritus ProfessorUniversity of Pennsylvania School of Medicine.CHICAGO, April 28 -- Men who were taking statins at the time of radical prostatectomy had a 30% reduction in prostate cancer recurrence, data reported here showed.Statin users also had lower PSA values and were more likely to haveUnknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-71764972748246531062009-04-28T09:22:00.002+10:002009-04-28T09:28:44.720+10:00American Urological Association Counters Mainstream Recommendations With New Best Practice Statement On PSA TestingScienceDaily (Apr. 27, 2009) — The American Urological Association (AUA) has issued new clinical guidance – which directly contrasts recent recommendations issued by other major groups – about prostate cancer screening, asserting that the prostate-specific antigen (PSA) test should be offered to well-informed, men aged 40 years or older who have a life expectancy of at least 10 years.The PSA testUnknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-20277882683430812342009-04-25T17:08:00.002+10:002009-04-25T17:12:11.190+10:003-D Research Model Tackles Prostate Cancer SpreadScienceDaily (Apr. 24, 2009) — One of the few research projects to study the spread of prostate cancer to the bones using three-dimensional models of tissue-engineered bone is underway at QUT's Institute of Health and Biomedical Innovation (IHBI).Shirly Sieh, a PhD student at IHBI, is studying the way cancer cells escape from the prostate through the bloodstream to form tumour colonies, most Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-92220420956348033582009-04-24T15:55:00.004+10:002009-04-24T16:08:03.078+10:00Colonoscopy—What to ExpectIn a previous post I outlined the reasons why I have been scheduled for a colonoscopy see: Managing Chronic Radiation Proctitis . Below, I offer some facts about the procedure for those who may find themselves in a similar situation.A colonoscopy is a diagnostic examination that allows a doctor to look inside the entire colon and rectum. The examination is used to determine the cause of Unknownnoreply@blogger.com0tag:blogger.com,1999:blog-459284884159163747.post-46261091991319286282009-04-24T15:25:00.004+10:002009-04-24T15:33:20.441+10:00AACR: Designer T Cells Attack Prostate CancerDENVER, April 21 -- Reprogrammed immune cells could become targeted "killing machines" against prostate cancer, a researcher said here.In the early stages of a phase I study, these reprogrammed T cells sharply reduced the levels of prostate specific antigen (PSA) in two patients with metastatic prostate cancer, according to Richard Junghans, M.D., Ph.D., of the Roger Williams Medical Center in Unknownnoreply@blogger.com0